Leu-Enkelphalin Tyr-Gly-Gly-Phe-Leu
[LEU5]-ENKEPHALIN
CAS: 58822-25-6
Molecular Formula: C28H37N5O7
Leu-Enkelphalin Tyr-Gly-Gly-Phe-Leu - Names and Identifiers
Leu-Enkelphalin Tyr-Gly-Gly-Phe-Leu - Physico-chemical Properties
| Molecular Formula | C28H37N5O7 |
| Molar Mass | 555.62 |
| Density | 1.274±0.06 g/cm3(Predicted) |
| Melting Point | 130-133 °C |
| Boling Point | 998.8±65.0 °C(Predicted) |
| Storage Condition | -20℃ |
| Physical and Chemical Properties | Biological activity [Leu5]-Enkephalin is a pentapeptide with morphine properties. As an opioid receptor (opioid receptors) agonist. |
Leu-Enkelphalin Tyr-Gly-Gly-Phe-Leu - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
Leu-Enkelphalin Tyr-Gly-Gly-Phe-Leu - Reference
| Reference Show more | 1. [IF=4.36] Xiaoli Wang et al."Network pharmacology combined with metabolomics to study the mechanism of Shenyan Kangfu Tablets in the treatment of diabetic nephropathy."J Ethnopharmacol. 2021 Apr;270:113817 |
Leu-Enkelphalin Tyr-Gly-Gly-Phe-Leu - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.8 ml | 8.999 ml | 17.998 ml |
| 5 mM | 0.36 ml | 1.8 ml | 3.6 ml |
| 10 mM | 0.18 ml | 0.9 ml | 1.8 ml |
| 5 mM | 0.036 ml | 0.18 ml | 0.36 ml |
Last Update：2024-01-02 23:10:35
Leu-Enkelphalin Tyr-Gly-Gly-Phe-Leu - Uses and synthesis methods
biological activity
[Leu5]-Enkephalin is a pentapeptide with morphine properties. As an opioid receptor (opioid receptors) agonist.
target
Human Endogenous Metabolite
in vitro study
Enkephalins (met- , leu-enkephalin, and enkephalin 8) and dynorphins are two classes of opioid peptides found in the spinal dorsal horn. Mu, delta, and kappa are three major subtypes of opioid receptors. Enkephalins are putative endogenous ligands for delta opioid receptors, and dynorphins are endogenous ligands for the kappa opioid receptors. Three receptor types resembling the vertebrate δ- and κ-type opioid receptors have been characterized pharmacologically in nervous tissues (e.g. K I =18.9 nM for Leu-enkephalin) and localized by autoradiography at CHH terminals in the SG of C. maenas. Leucine-enkephalin is a pentapeptides with morphine like properties, naturally present in mammalian brain.
Last Update：2024-04-10 22:29:15
Leu-Enkelphalin Tyr-Gly-Gly-Phe-Leu - Nature
| melting point | 130-133 °C |
| specific rotation | 32.3°(c=9,メタノール) |
| boiling point | 998.8±65.0 °C(Predicted) |
| density | 1.274±0.06 g/cm3(Predicted) |
| storage conditions | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| acidity coefficient (pKa) | 3.40±0.10(Predicted) |
| water solubility | Soluble in water (1 mg/ml ). |
Last Update：2024-04-09 21:31:46
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Leu-Enkelphalin Tyr-Gly-Gly-Phe-Leu
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5-磺基-1,3,-苯二甲酸二(2-羟基乙基)酯的一钠盐
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Disodium lauryl polyether sulfosuccinate
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5-氨基-3-苯基异噁唑
5-磺基-1,3,-苯二甲酸二(2-羟基乙基)酯的一钠盐
766-11-0
1-氯-4-丙氧基-9H-噻吨酮-9-酮
咪唑并[1,2-b]哒嗪-6-基甲胺
N2-(4-FLUOROPHENYL)PYRIDINE-2,3-DIAMINE DIHYDROCHLORIDE
Hexanoic acid, 4-methyl-3,5-dioxo-, ethyl ester
Disodium lauryl polyether sulfosuccinate
2-(2,6-Dimethylmorpholin-4-yl)propanoic acid hydrochloride